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Saints vs. Rams Prediction, Best Bets & Odds for Thursday, 12/21

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NFL Week 16 kicks off with a Thursday Night Football matchup that sees the New Orleans Saints hosting the Los Angeles Rams. These are two teams that are eyeing the postseason in a crowded NFC, making this matchup that much more important. To get you set for it, our experts have provided their best Saints vs. Rams prediction for their TNF game.

We’ll even be sharing how you can use any Saints vs. Rams best bets to snag a DraftKings Sportsbook sign-up bonus for guaranteed rewards valuing at least $150, so you won’t want to miss out.

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SAINTS VS. RAMS PREDICTION: Under 44.5 points (-110 at DraftKings Sportsbook)

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New Orleans Saints vs. Los Angeles Rams Prediction for Thursday's Game: TNF

With the weak NFC South and the NFC Wild Card wide open, the Saints and Rams both have a great shot at making the playoffs. They’re also both coming off convincing home wins, and along with a short week, it can certainly make locking in Saints vs. Rams best bets difficult.

With the point spread a bit north of the key number of three, we’d be inclined to back New Orleans. However, with the travel to LA and WR Chris Olave having fewer days to get healthy, we’d rather attack the over/under with our Saints vs. Rams prediction. In that respect, we’re predicting a low-scoring game, so let’s explain why.

Best Bets for Saints vs. Rams Featuring Under 44.5

First and foremost, the aforementioned Olave plays a part in our Saints vs. Rams prediction focusing on the under. That’s one less explosive weapon as a scoring threat if he’s unable to suit up, and even if he’s on the field, he’s clearly not 100% healthy.

Even Saints QB Derek Carr seems to have something come up on a nearly weekly basis, and of course, WR Michael Thomas has been on injured reserve. Therefore, New Orleans has been relying on a stout defense to put them in position to win the NFC South. They got after New York Giants QB Tommy DeVito early and often this past weekend, ultimately allowing just six points.

That’s back-to-back games allowing just six points, and while those games were at home, they’ve also already recorded a road shutout this season. Similarly, the Rams defense has looked strong with DT Aaron Donald and company generating pressure.

Their 20 points allowed to the Washington Commanders this past Sunday is a bit deceiving, as 13 of them were in the fourth quarter when the game was firmly in control with a 20-0 score. In their five games prior to that matchup, they allowed over 20 points just once. We’re anticipating the first team to 20 will win this game, making our Saints vs. Rams prediction under 44.5 points (-110 at DraftKings Sportsbook).

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Betting Odds for Saints vs. Rams at DraftKings Sportsbook

We’ve also shared the latest Saints vs. Rams odds at DraftKings Sportsbook, and based on those prices, an $11 bet profits $10 as long as the game ends with 44 or fewer points.

Point spread:

  • New Orleans Saints +4 (-110) vs. Los Angeles Rams -4 (-110)

Money line:

  • New Orleans Saints (+180) vs. Los Angeles Rams (-218)

Total (over/under):

  • Over 44.5 (-110) vs. Under 44.5 (-110)

Injury Report for Saints vs. Rams

Let’s wrap up all things surrounding our Saints vs. Rams prediction by providing the latest injury news for both sides:

NO Saints:

  • Chris Olave
  • Ryan Ramczyk
  • Isaiah Foskey
  • Kendre Miller

LA Rams:

  • Tutu Atwell
  • Rob Havenstein
  • Ahkello Witherspoon
  • Stetson Bennett
  • Tre Tomlinson

With it being so early in the week, we don’t have true designations just yet, so the players above are simple ones to keep an eye on as we approach Thursday night. Until then, be sure to create a new account at DraftKings to place your Saints vs. Rams best bets while claiming $150+ in guaranteed bonuses.

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