Colts-Titans Week 7 Odds, Lines and Spread

The Titans are home favorites against the Colts in Week 7.

Flying under the radar is the success of both the Titans and Colts, who have combined to post 6-2 straight-up (SU) and against the spread (ATS) marks over their last four games. 

The Colts scored the game-winning touchdown in Week 6 against the Jaguars with only 17 seconds remaining to improve to 3-2-1.

The Titans, who enter Week 7 off their bye, will try to extend their dominance over the Colts. Ryan Tannehill and Tennessee are 4-0 SU and ATS in the last four meetings against Indianapolis. The Titans are also 3-0 SU and ATS since suffering back-to-back losses against the Giants and Bills to open the season.

Colts vs. Titans Odds

Moneyline: Indianapolis (+125) | Tennessee (-150)
Spread: IND +2.5 (+100) | TEN -2.5 (-118)
Point Total: 42.5 – Over (-110) | Under (-110)
Game Info: Oct. 23 2022 | 1 p.m. ET | CBS

Colts Straight-Up Record: 3-2-1
Colts Against The Spread Record: 3-3

Titans Straight-Up Record: 3-2
Titans Against The Spread Record: 3-2

Bet on Colts-Titans at SI Sportsbook

Odds and Betting Insights

The Titans beat the Colts, 24-17, in Week 4 as 4.5-point road underdogs. Tennessee, who started 0-2 SU and ATS, has ripped off  3-0 SU and ATS marks that has bettors once again eager to back Derrick Henry and the boys.

The Colts, who started off slow with a tie against Houston and a shutout loss at Jacksonville, have won three of their last four games both SU and against the number. If star running back Jonathan Taylor, who has missed the last two games, can return to action then the Colts will be a live ‘dog in Week 7.

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Frankie Taddeo is a successful high-stakes fantasy football player who created the first-ever DFS program ever offered in a Las Vegas sportsbook. Frankie is SI Betting's Senior Analyst and provides his significant experience and resources in the sports betting scene. You can follow Frankie on Twitter @Frankie_Fantasy for his latest betting and fantasy insights from Las Vegas.