Cardinals-Rams Week 10 Odds, Lines and Spread

The Cardinals are 8-2 against the spread in their last 10 games as road underdog.

Injury concerns surrounding Rams quarterback Matthew Stafford have impacted the point spread immensely in the Week 10 showdown with Kyler Murray and Arizona.

Los Angeles, who announced that Stafford entered the NFL’s concussion protocol on Tuesday, have been adjusted from 4-point home favorites to only a 1.5-point demand against the Cardinals.

Arizona, who has lost four of their last five games (1-4 SU; 2-3 ATS), reside in last place in the NFC West. On the flip side, things have not been much better for the Rams, who also have won just once over their last five games (1-4 SU) while posting an accompanying dismal against the spread (1-3-1 ATS) mark.

These two division foes met back in Week 3, with the Rams earning a 20-12 victory as 3.5-point road favorites. Los Angeles has recently dominated the Cardinals in the series, winning nine of the last ten meetings (9-1 SU) while boasting an impressive 8-1-1 ATS.

Cardinals vs. Rams Odds

Moneyline: ARIZONA (+105) | LA RAMS (-125)
Spread: ARZ +1.5 (-110) | LAR -1.5 (-118)
Total: 40.5– Over: (-118) | Under: 40.5 (-110)
Game Info: Nov. 13, 2022 | 4:25 p.m. ET | Fox

Cardinals Straight-Up Record: 3-6
Cardinals Against The Spread Record: 4-5

Rams Straight-Up Record: 3-5
Rams Against The Spread Record: 2-5-1

Bet on Cardinals-Rams at SI Sportsbook

Odds and Betting Insights

Despite employing arguably the best wide receiver in the NFL, Los Angeles has struggled to post consistent offensive production. Cooper Kupp, who ranks among the league leaders in receptions (72), receiving yards (813) and total touchdowns (7), has only resulted in the Rams ranking only 29th in scoring, averaging a disappointing 16.4 points per game.

Things could get worse for the Rams' offense as Stafford's status is in doubt, leaving the club to potentially turn to backup John Wolford. Bettors need to monitor Stafford's availability ahead of kickoff on Sunday.

Arizona wideout DeAndre Hopkins, who is averaging 99.3 receiving yards per game while scoring two touchdowns since his return from suspension, draws a tough assignment against a Rams defense that has only allowed three touchdowns to opposing wideouts over the last eight games.

Murray, who threw for 314 yards in the first meeting with the Rams this season, has stepped up his output, throwing six touchdowns over his last three games. Murray averages 6.1 yards per rush and will face a stingy Rams run defense allowing the fourth-fewest rushing yards per game (98.4). In the Week 3 matchup, Los Angeles held the dual-threat signal-caller to a season-low eight rushing yards.

Bettors can take part in SI Sportsbook’s free Perfect 10 contest each week during the NFL season. The weekly game requires bettors to make 10 selections against the spread for a chance at a share of a $10,000 prize. Every bettor who picks at least six games correctly will be awarded consolation prizes in the form of free bets.

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Frankie Taddeo is a successful high-stakes fantasy football player who created the first-ever DFS program ever offered in a Las Vegas sportsbook. Frankie is SI Betting's Senior Analyst and provides his significant experience and resources in the sports betting scene. You can follow Frankie on Twitter @Frankie_Fantasy for his latest betting and fantasy insights from Las Vegas.