49ers vs. Rams Prediction, Odds, Spread, Injuries, Trends for NFL Week 3

Iain MacMillan | Sep 17, 2024

Sep 17, 2023; Inglewood, California, USA; San Francisco 49ers quarterback Brock Purdy (13) escapes the grip on Los Angeles Rams safety Quentin Lake (37) in the first half at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images / Jayne Kamin-Oncea-Imagn Images

The San Francisco 49ers stumbled in Week 2, falling to the Minnesota Vikings as 6.5-point favorites in one of the many upsets that took place in the second week of the season.

They'll try to get back on track when they hit the road to take on the Los Angeles Rams, who are one of the most injured teams in the league. The Rams are missing key players on both sides of the ball for extended period of time, including their top two wide receivers, Puka Nacua and Cooper Kupp.

Can they survive against the defending NFC West champs? Let's find out what the oddsmakers think.

49ers vs. Rams Odds, Spread, and Total

Spread

49ers -7.5 (-105)
Rams +7.5 (-115)

Moneyline

49ers -360
Rams +290

Total

OVER 43.5 (-115)
UNDER 43.5 (-105)

49ers vs. Rams How to Watch

Date: Sunday, Sept. 22
Time: 4:25 p.m. EST
Venue: SoFi Stadium
How to Watch (TV): FOX
49ers record: 1-1
Rams record: 0-2

49ers vs. Rams Betting Trends

49ers are 1-5 ATS in their last six games
The OVER is 8-4 in the 49ers' last 12 games
49ers are 7-2 ATS in their last nine games vs. Rams
49ers are 12-1 straight up in their last 13 games vs. NFC West opponents
Rams are 7-3 ATS in their last 10 games
The OVER is 7-3 in the Rams' last 10 games
Rams are 1-5 ATS in their last six home games vs. 49ers

49ers vs. Rams Injury Reports

49ers Injury Report

Dee Winters, LB - Questionable
Talanoa Hufanga, S - Questionable
Deebo Samuel, WR - Doubtful

Rams Injury Report

Davis Allen, TE - Questionable
Jonah Jackson, G - Doubtful
Joshua Karty, K - Questionable
Cooper Kupp, WR - Doubtful
John Johnson III, S - Doubtful

49ers vs. Rams Key Players to Watch

San Francisco 49ers

Brandon Aiyuk: With Deebo Samuel likely missing some time, Brandon Aiyuk needs to step up. He hasn't been his usual self through the first two games this season as he gets caught up after missing training camp due to a contract holdout. The 49ers need him now more than ever.

Los Angeles Rams

Tyler Johnson: With no Puka Nacua or Cooper Kupp for several weeks, Tyler Johnson and Demarcus Robinson need to step up in a big way if the Rams want to stay competitive this season. Johnson has the second most receptions on the team so far in 2024 with seven, so we'll see what he can bring to the table as a primary target moving forward.

49ers vs. Rams Prediction and Pick

As I broke down in this week's edition of the "Road to 272 Bets", we should all stay far away from betting on the Rams until further notice:

It's time to sell all your stock in the Rams. This has been a disastrous start to the season. Not only are they 0-2, but they're the most injured team in the NFL. Darious Williams, Joe Noteboom, Steve Avila, and Puka Nacua are all on injured reserve. Cooper Kupp, John Johnson, and Jonah Jackson are doubtful for this game and both may land on injured reserve too.

On top of all that they're 31st in the NFL in Net Yards per Play at -1.9 and are giving up a disgusting 9.3 yards per pass attempt, the most in the NFL by an entire yard. I see no reason to justify a bet on Los Angeles at this point in the season, especially against the 49ers.

I'll lay the points with San Fran.

Pick: 49ers -7.5 (-105)