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Can Mississippi State win its first SEC game on Saturday with ranked Missouri coming to Starkville?

Best College Football Upset Picks for Week 13: Can Mississippi State Score First SEC Win?

Can Mississippi State win its first SEC game on Saturday with ranked Missouri coming to Starkville?

Best College Football Upset Picks for Week 13: Can Mississippi State Score First SEC Win?

Breaking down the best upset picks for Week 13 of the College Football season.

CFB Betting Picks

Nov 16, 2024; College Station, Texas, USA; Texas A&M Aggies quarterback Marcel Reed (10) looks on during the first quarter against the New Mexico State Aggies at Kyle Field. Mandatory Credit: Maria Lysaker-Imagn Images

Texas A&M vs. Auburn Prediction, Odds and Key Players to Watch for College Football Week 13

Oct 26, 2024; Minneapolis, Minnesota, USA; Minnesota Golden Gophers quarterback Max Brosmer (16) throws the ball against the Maryland Terrapins during the first half at Huntington Bank Stadium. Mandatory Credit: Matt Krohn-Imagn Images

Penn State vs. Minnesota Prediction, Odds and Key Players to Watch for College Football Week 13

Best picks against the spread for college football Week 13

First to Forde: Best College Football Picks Against the Spread for Week 13

Nov 16, 2024; Boulder, Colorado, USA; Colorado Buffaloes defensive back Travis Hunter (12) looks on during the first quarter against the Utah Utes at Folsom Field. Mandatory Credit: Ron Chenoy-Imagn Images

Best College Football Straight Up Picks for Every Top 25 Game in Week 13

Ohio State Buckeyes quarterback Will Howard (18) calls out the defense during the NCAA football game against the Northwestern Wildcats at Wrigley Field in Chicago on Monday, Nov. 18, 2024. Ohio State won 31-7.

College Football Picks Against the Spread for Every Top 25 Game in Week 13

Nov 9, 2024; Oxford, Mississippi, USA; Mississippi Rebels quarterback Jaxson Dart (2) hands the ball off to running back Ulysses Bentley IV (24) during the first half against the Georgia Bulldogs at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images

Ole Miss vs. Florida Prediction, Odds and Key Players to Watch for College Football Week 13

Nov 16, 2024; Tuscaloosa, Alabama, USA; Alabama Crimson Tide quarterback Jalen Milroe (4) prepares to throw during warmups prior to a game against Mercer Bears at Bryant-Denny Stadium. Mandatory Credit: Will McLelland-Imagn Images

Alabama vs. Oklahoma Prediction, Odds and Key Players to Watch for College Football Week 13

Notre Dame quarterback Riley Leonard (13) throws the ball during a NCAA college football game against Virginia at Notre Dame Stadium on Saturday, Nov. 16, 2024, in South Bend.

Army vs. Notre Dame Prediction, Odds and Key Players to Watch for College Football Week 13

Nov 16, 2024; Manhattan, Kansas, USA; Arizona State Sun Devils quarterback Sam Leavitt (10) hands off to running back Cam Skattebo (4) against the Kansas State Wildcats during the second quarter at Bill Snyder Family Football Stadium. Mandatory Credit: Scott Sewell-Imagn Images

BYU vs. Arizona State Prediction, Odds and Key Players to Watch for College Football Week 13

Nov 16, 2024; Boulder, Colorado, USA; Colorado Buffaloes quarterback Shedeur Sanders (2) looks on before the game against the Utah Utes at Folsom Field. Mandatory Credit: Ron Chenoy-Imagn Images

Colorado vs. Kansas Prediction, Odds and Key Players to Watch for College Football Week 13

Ohio State Buckeyes wide receiver Jeremiah Smith (4) catches a touchdown pass in front of Nebraska Cornhuskers defensive back Isaac Gifford (2) during the first half of the NCAA football game at Ohio Stadium in Columbus on Saturday, Oct. 26, 2024.

Indiana vs. Ohio State Prediction, Odds and Key Players to Watch for College Football Week 13

Sep 20, 2024; Pullman, Washington, USA; San Jose State Spartans wide receiver Nick Nash (3) stiff arms Washington State Cougars defensive back Kapena Gushiken (4) in the second at Gesa Field at Martin Stadium. Washington State Cougars won 54-52 in double overtime. Mandatory Credit: James Snook-Imagn Images

UNLV vs. San Jose State Prediction, Odds and Key Players to Watch for College Football Week 13

Nov 16, 2024; West Lafayette, Indiana, USA; Purdue Boilermakers quarterback Hudson Card (1) throws a pass during the first quarter against the Penn State Nittany Lions at Ross-Ade Stadium. Mandatory Credit: Marc Lebryk-Imagn Images

Purdue vs. Michigan State Prediction, Odds and Key Players to Watch for College Football Week 13

Sep 14, 2024; Austin, Texas, USA; Texas-San Antonio quarterback Owen McCown (2) throws a pass during the first half against Texas Longhorns at Darrell K Royal-Texas Memorial Stadium. Mandatory Credit: Scott Wachter-Imagn Images

Temple vs. UTSA Prediction, Odds and Key Players to Watch for College Football Week 13

Nov 2, 2024; Raleigh, North Carolina, USA; North Carolina State Wolfpack quarter back CJ Bailey (16) drops a pass back in the second half against Stanford Cardinals at Carter-Finley Stadium. Mandatory Credit: Zachary Taft-Imagn Images

North Carolina State vs. Georgia Tech Prediction, Odds and Key Players to Watch for College Football Week 13

Sep 7, 2024; Seattle, Washington, USA; Eastern Michigan Eagles quarterback Cole Snyder (15) during warmups before the game against the Washington Huskies at Alaska Airlines Field at Husky Stadium. Mandatory Credit: Steven Bisig-Imagn Images

Buffalo vs. Eastern Michigan Prediction, Odds and Key Players to Watch for College Football Week 13

Sep 14, 2024; Starkville, Mississippi, USA; Toledo Rockets quarterback Tucker Gleason (4) looks to pass against the Mississippi State Bulldogs during the first quarter at Davis Wade Stadium at Scott Field. Mandatory Credit: Matt Bush-Imagn Images

Ohio vs. Toledo Prediction, Odds and Key Players to Watch for College Football Week 13

Sep 28, 2024; Raleigh, North Carolina, USA; Northern Illinois Huskies quarter back Ethan Hampton (2) throws a pass against the North Carolina State Wolfpack during second quarter at Carter-Finley Stadium. Mandatory Credit: Zachary Taft-Imagn Images

Northern Illinois vs. Miami (Ohio) Prediction, Odds and Key Players to Watch for College Football Week 13

Akron quarterback Ben Finley looks for a receiver during the second half of a game against Eastern Michigan on Saturday, Oct. 26, 2024 in Akron, Ohio.

Akron vs. Kent State Prediction, Odds and Key Players to Watch for College Football Week 13

Aug 30, 2024; Madison, Wisconsin, USA; Western Michigan Broncos quarterback Hayden Wolff (11) during the game against the Wisconsin Badgers at Camp Randall Stadium. Mandatory Credit: Jeff Hanisch-Imagn Images

Western Michigan vs. Central Michigan Prediction, Odds and Key Players to Watch for College Football Week 13

Nov 9, 2024; Atlanta, Georgia, USA; Miami Hurricanes quarterback Cam Ward (1) scrambles against the Georgia Tech Yellow Jackets in the second quarter at Bobby Dodd Stadium at Hyundai Field. Mandatory Credit: Brett Davis-Imagn Images

2024 Heisman Trophy Odds: Cam Ward is Best Bet to Challenge to Travis Hunter

Ohio State Buckeyes running back TreVeyon Henderson (32) celebrates with wide receiver Jeremiah Smith (4) after Henderson scored a touchdown in the second half at Ohio Stadium on Saturday, Nov. 9, 2024 in Columbus, Ohio.

College Football Week 13 Opening Odds: Ohio State Opens Favored vs. Indiana in College Football Playoff Preview

Oct 26, 2024; Nashville, Tennessee, USA; Texas Longhorns quarterback Quinn Ewers (3) passes the ball against the Vanderbilt Commodores during the second half at FirstBank Stadium. Mandatory Credit: Steve Roberts-Imagn Images

Best College Football Bets for Week 12: How to Bet Over/Under in Texas vs. Arkansas, Tennessee vs. Georgia

Nov 8, 2024; Pasadena, California, USA; UCLA Bruins running back T.J. Harden (25) carries for a gain in the first half against the Iowa Hawkeyes at the Rose Bowl. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Best College Football Props for UCLA vs. Washington in Week 12