NFL Straight-Up Moneyline Picks for Every Game in Week 4

The Sports Illustrated team breaks down their picks to win all 16 games in Week 4 of the 2024 NFL season.

SI Staff | Sep 25, 2024

The Sports Illustrated team breaks down their picks to win all 16 games in Week 3 of the 2024 NFL season. /

We're three weeks into the 2024 NFL season and if you want an idea of just how unpredictable this season has been so far, just take a look at how our NFL experts have done with their picks so far.

The biggest favorites each week continuously are finding ways to lose. In fact, underdogs of 5.5 points or more are 10-6 so far this season, decimating Survivor Pools and anyone who's trying to predict the winner of every game.

Underdogs of +5.5 or more at the closing number are now 14-2 ATS and 10-6 outright this season.
— Iain MacMillan (@IainMacBets) September 24, 2024

We march on to Week 4 of the season, seeking some level of normalcy to the 2024 NFL campaign. Let's take a look at the full records of all our Sports Illustrated staff before we dive into their Week 4 picks.

Week 3 Results

Albert Breer, Senior NFL Reporter (7-9, -4.13 units)
Mitch Goldich, Senior Editor (9-7, -0.44 units)
Gilberto Manzano, NFL Staff Writer (6-10, -6.15 units)
Conor Orr, Senior Writer (10-6 +4.03 units)
John Pluym, NFL Managing Editor (8-8, -1.14 units)
Matt Verderame, NFL Staff Writer (9-7, -0.82 units)
Jennifer Piacenti, Senior Betting and Fantasy Analyst (8-8, -2.12 units)
Peter Dewey, Senior Editor Betting (6-10, -6.15 units)
Iain MacMillan, Senior Editor Betting (4-12, -7.86 units)

Season-to-Date Results

Albert Breer, Senior NFL Reporter (25-23, -6.97 units)
Mitch Goldich, Senior Editor (30-18, +1.72 units)
Gilberto Manzano, NFL Staff Writer (23-25, -11.08 units)
Conor Orr, Senior Writer (27-21, +4.13 units)
John Pluym, NFL Managing Editor (26-22, -4.54 units)
Matt Verderame, NFL Staff Writer (29-19, -0.82 units)
Jennifer Piacenti, Senior Betting and Fantasy Analyst (28-20, -1.82 units)
Peter Dewey, Senior Editor Betting (25-23, -5.48 units)
Iain MacMillan, Senior Editor Betting (20-28, -12.73 units)

Special shoutout to Conor Orr, who not only was the only person able to turn a profit in Week 3, but he's also leading all writers with a 27-21 overall record at +4.13 units.

Let's take a look at everyone's picks for Week 4. All odds listed are via DraftKings Sportsbook.

NFL Week 4 Picks

The Sports Illustrated team makes their picks for NFL Week 4. /

Cowboys (-245) vs. Giants (+200)

Albert Breer: Cowboys
Mitch Goldich: Cowboys
Gilberto Manzano: Cowboys
Conor Orr: Giants
John Pluym: Cowboys
Matt Verderame: Cowboys
Jennifer Piacenti: Cowboys
Peter Dewey: Cowboys
Iain MacMillan: Cowboys

Eagles (-135) vs. Buccaneers (+114)

Albert Breer: Buccaneers
Mitch Goldich: Eagles
Gilberto Manzano: Buccaneers
Conor Orr: Buccaneers
John Pluym: Eagles
Matt Verderame: Eagles
Jennifer Piacenti: Buccaneers
Peter Dewey: Eagles
Iain MacMillan: Eagles

Broncos (+275) vs. Jets (-345)

Albert Breer: Jets
Mitch Goldich: Jets
Gilberto Manzano: Broncos
Conor Orr: Jets
John Pluym: Jets
Matt Verderame: Jets
Jennifer Piacenti: Jets
Peter Dewey: Jets
Iain MacMillan: Jets

Vikings (+120) vs. Packers (-142)

Albert Breer: Vikings
Mitch Goldich: Vikings
Gilberto Manzano: Vikings
Conor Orr: Vikings
John Pluym: Vikings
Matt Verderame: Packers
Jennifer Piacenti: Vikings
Peter Dewey: Packers
Iain MacMillan: Vikings

Saints (+102) vs. Falcons (-122)

Albert Breer: Saints
Mitch Goldich: Saints
Gilberto Manzano: Saints
Conor Orr: Falcons
John Pluym: Falcons
Matt Verderame: Falcons
Jennifer Piacenti: Saints
Peter Dewey: Falcons
Iain MacMillan: Falcons

Bengals (-205) vs. Panthers (+170)

Albert Breer: Bengals
Mitch Goldich: Bengals
Gilberto Manzano: Panthers
Conor Orr: Bengals
John Pluym: Bengals
Matt Verderame: Bengals
Jennifer Piacenti: Bengals
Peter Dewey: Bengals
Iain MacMillan: Panthers

Jaguars (+240) vs. Texans (-298)

Albert Breer: Texans
Mitch Goldich: Texans
Gilberto Manzano: Texans
Conor Orr: Texans
John Pluym: Texans
Matt Verderame: Texans
Jennifer Piacenti: Texans
Peter Dewey: Texans
Iain MacMillan: Jaguars

Steelers (-122) vs. Colts (+102)

Albert Breer: Steelers
Mitch Goldich: Steelers
Gilberto Manzano: Colts
Conor Orr: Steelers
John Pluym: Colts
Matt Verderame: Steelers
Jennifer Piacenti: Steelers
Peter Dewey: Steelers
Iain MacMillan: Colts

Rams (+124) vs. Bears (-148)

Albert Breer: Rams
Mitch Goldich: Rams
Gilberto Manzano: Rams
Conor Orr: Bears
John Pluym: Rams
Matt Verderame: Rams
Jennifer Piacenti: Bears
Peter Dewey: Rams
Iain MacMillan: Bears

Commanders (+142) vs. Cardinals (-170)

Albert Breer: Cardinals
Mitch Goldich: Cardinals
Gilberto Manzano: Commanders
Conor Orr: Cardinals
John Pluym: Commanders
Matt Verderame: Cardinals
Jennifer Piacenti: Cardinals
Peter Dewey: Cardinals
Iain MacMillan: Cardinals

Patriots (+390) vs. 49ers (-520)

Albert Breer: 49ers
Mitch Goldich: 49ers
Gilberto Manzano: 49ers
Connor Orr: 49ers
John Pluym: Rams
Matt Verderame: 49ers
Jennifer Piacenti: 49ers
Peter Dewey: 49ers
Iain MacMillan: 49ers

Browns (-102) vs. Raiders (-118)

Albert Breer: Browns
Mitch Goldich: Raiders
Gilberto Manzano: Raiders
Connor Orr: Browns
John Pluym: Raiders
Matt Verderame: Browns
Jennifer Piacenti: Browns
Peter Dewey: Browns
Iain MacMillan: Raiders

Chiefs (-425) vs. Chargers (+330)

Albert Breer: Chiefs
Mitch Goldich: Chiefs
Gilberto Manzano: Chiefs
Connor Orr: Chiefs
John Pluym: Chiefs
Matt Verderame: Chiefs
Jennifer Piacenti: Chiefs
Peter Dewey: Chiefs
Iain MacMillan: Chiefs

Bills (+110) vs. Ravens (-130)

Albert Breer: Bills
Mitch Goldich: Bills
Gilberto Manzano: Bills
Connor Orr: Ravens
John Pluym: Bills
Matt Verderame: Ravens
Jennifer Piacenti: Bills
Peter Dewey: Bills
Iain MacMillan: Ravens

Titans (-108) vs. Dolphins (-112)

Albert Breer: Titans
Mitch Goldich: Dolphins
Gilberto Manzano: Dolphins
Connor Orr: Titans
John Pluym: Titans
Matt Verderame: Dolphins
Jennifer Piacenti: Titans
Peter Dewey: Titans
Iain MacMillan: Titans

Seahawks (+150) vs. Lions (-180)

Albert Breer: Lions
Mitch Goldich: Lions
Gilberto Manzano: Seahawks
Connor Orr: Lions
John Pluym: Lions
Matt Verderame: Lions
Jennifer Piacenti: Seahawks
Peter Dewey: Lions
Iain MacMillan: Seahawks