Orioles vs. Yankees Prediction, Odds and Probable Pitchers for Wednesday, Sept. 25 (How to Bet Total)

Betting odds, pick and prediction for the Baltimore Orioles-New York Yankees matchup on Wednesday night.
Baltimore Orioles starting pitcher Zach Eflin.
Baltimore Orioles starting pitcher Zach Eflin. / Jonathan Dyer-Imagn Images

Another day, another chance for the New York Yankees to clinch the AL East.

New York dropped Tuesday’s game 5-3, giving the O’s hope to still win the division this season. 

The Yankees are favored again on Wednesday, but they won't have Nestor Cortes on the mound after he was scratched due to an elbow issue. It's possible Marcus Stroman will start in his place.

Baltimore counters with Zach Eflin, who has been elite since the trade deadline.

This game has a low total at 7.5, but betting on the total may be the way to go with both starters thriving over the last two months.

Here’s a breakdown of the odds, key players to watch and my best bet on Wednesday. 

Orioles vs. Yankees Odds, Run Line and Total

Odds via DraftKings Sportsbook.

Run Line

  • Orioles +1.5 (-192)
  • Yankees -1.5 (+1560)

Moneyline

  • Orioles: +114
  • Yankees: -135

Total

  • 8 (Over -110/Under -110)

Orioles vs. Yankees Probable Pitchers

  • Baltimore: Zach Eflin (10-9. 3.53 ERA)
  • New York: TBD (Nestor Cortes scratched)

Orioles vs. Yankees How to Watch

  • Date: Wednesday, Sept. 25
  • Time: 7:05 p.m. EST
  • Venue: Yankee Stadium
  • How to Watch (TV): MASN, YES Network
  • Orioles record: 87-70
  • Yankees record: 92-65

Orioles vs. Yankees Key Players to Watch

Baltimore Orioles

Zach Eflin: Acquired by the O’s at the trade deadline, Elfin has been lights out since he joined Baltimore, posting a 2.31 ERA and leading them to a 6-2 record in eight starts. Eflin pitched 12 innings against the Yankees earlier this year with Tampa, allowing five runs and 11 hits. 

New York Yankees 

Aaron Judge: Judge smacked his 56th homer of the season on Tuesday night, going 1-for-3 with a walk in the Yankees’ loss. This is a tough matchup for him on Wednesday, as he’s just 3-for-17 with 10 strikeouts in his career against Eflin. 

Orioles vs. Yankees Prediction and Pick

With Cortes scratched on Wednesday, the total in this game has gone from 7.5 to 8, giving a little more wiggle room for my best bet of the night.

The O’s have been elite when Eflin is on the mound (6-2 straight up), so I don’t love fading the O’s after they picked up a win in a less favorable pitching matchup on Tuesday night. 

New York needs just one win to clinch the AL East, but I’m not sold on that coming in this game with the team potentially turning to Stroman or a bullpen game in place of Cortes.

Instead, I’m targeting the UNDER given how well Eflin has fared as of late. Since joining the O’s, Eflin has had four starts fall short of this total and seven of them with just eight total runs or less. 

Pick: UNDER 8 (-110)


Odds refresh periodically and are subject to change.

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Peter Dewey

PETER DEWEY

Peter is a senior editor for Sports Illustrated Betting. He has worked as a writer and editor for BetSided, NBC Sports, the Connecticut Sun and the Meriden Record-Journal covering the NBA, WNBA, NFL, MLB, and more. A New York City resident, he is a hoops fanatic with a soft spot for his New York Knicks.