Kalin Lucas had 18 points, and the Spartans advance to play Louisville on Sunday for a trip to the Final Four.
Goran Suton scored 20 points and Michigan State was steady from the foul line, defeating defending NCAA champion Kansas.
Ty Lawson and North Carolina breezed to another regional final. Lawson scored 17 of his 19 points in the first half.
Tyler Hansbrough added 24 points and 10 rebounds for North Carolina, which won its 99th NCAA tournament game, breaking a tie with Kentucky for the most by any school.
Earl Clark had 19 points and nine rebounds and the top-seeded team in the NCAA tournament delivered one of the most crushing blowouts in regional round history.
Jerry Smith and Louisville proved it was the best in the Big East. Now, the Cardinals are showing just how mighty they might be.
Blake Griffin scored 30 points and had 14 rebounds, as the second-seeded Sooners beat Syracuse and advanced to their first regional final since 2003.
Tony Crocker added a career-high 28 points, and the Sooners seemed unstoppable.
Sam Young (23) led Pitt with 19 points, Levance Fields had 14, and DeJuan Blair had 10 points and 17 rebounds in the East semifinal victory. The Panthers overcame an eight-point halftime deficit.
Blair helped Pitt earn its first regional final berth since 1974 with a victory over Xavier.
Hasheem Thabeet, the Big East player of the year, scored 15 points, had 15 rebonds and blocked four shots, and Connecticut overcame a sluggish first half to defeat Purdue.
A.J. Price scored 10 of his 15 points after halftime to help beat the No. 5 seed.
Dante Cunningham scored 14 points with 11 rebounds and third-seeded Villanova beat Duke for the first time in more than 50 years.
The Wildcats (29-7) will play Big East rival Pittsburgh (31-4), the top seed in the East, on Saturday for a trip to the Final Four.
J.T. Tiller scored a career-high 23 points - 15 more than his season average - and Missouri held off Memphis' frantic rally for a win in the semifinals of the West Regional.
DeMarre Carroll and the Missouri Tigers stunned No. 2 seed Memphis and advanced to the Elite Eight for the first time since 2002.