College Football Week 10 Picks: Unbeaten MSU, Wake Forest in Tricky Road Spots

Who will win Michigan State vs Purdue, Wake Forest vs UNC, Oregon vs Washington and more Week 10 games?

Week 10 of the 2021 season features one key change compared to the weeks prior: the first College Football Playoff rankings are out, giving everyone in the list of 25 teams a better idea of where they stand.

For Michigan State, its placement at No. 3 puts it firmly in the race for one of the four spots. But a trip to West Lafayette could make that ranking short-lived; Purdue has already knocked off one top-10 team this season. Fellow undefeated program Wake Forest, at No. 9 in the playoff rankings, has some work to do, and can't afford a slip-up with a visit to Chapel Hill to face UNC.

Elsewhere, Auburn and Texas A&M battle in a key SEC clash in College Station, Oregon takes on Washington in Seattle, and one-loss Oklahoma State and Baylor both hit the road in the Big 12. 

Week 10 Best Bets: Composite Rankings Pick the Winners

Who has the edge in 16 of Week 10's biggest games? Our writers' and editors' picks are in.

Standings to Date:

John Garcia: 93–52
Molly Geary: 92–53
Ross Dellenger: 86–59
Richard Johnson: 82–63
Pat Forde: 79–66