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Notre Dame vs. Louisville football predictions

Notre Dame vs. Louisville football prediction: What the analytics say

Louisville running back Jawhar Jordan scored on a 21 yard run in the fourth quarter as the Louisville Cardinals defeated the Notre Dame Fighting Irish, 33-20 on Saturday, Oct. 7, 2023

Depth Charts: Louisville vs. Notre Dame

Louisville Cardinals head coach Jeff Brohm walks through the card march ahead of their game on Saturday, Aug. 31, 2024 at L&N Federal Credit Union Stadium in Louisville, Ky.

Jeff Brohm, Louisville 'Excited' for Opportunity to Face Notre Dame

Jan 14, 2024; Detroit, Michigan, USA; Los Angeles Rams wide receiver Tutu Atwell (5) runs after a catch for a touchdown during the first half of a 2024 NFC wild card game against the Detroit Lions at Ford Field. Mandatory Credit: Lon Horwedel-Imagn Images

Cards in the NFL: 2024 Week 3

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Oct 7, 2023; Louisville, Kentucky, USA; Louisville Cardinals running back Jawhar Jordan (25) runs the ball against Notre Dame Fighting Irish linebacker Marist Liufau (8) and linebacker Jack Kiser (24) during the second half at L&N Federal Credit Union Stadium. Louisville defeated Notre Dame 33-20.

How to Watch: Louisville Cardinals vs. Notre Dame Fighting Irish

Ohio State players take the field before a recent game.

Forde-Yard Dash: Five Undefeated Teams With Big Week 5 Challenges

Louisville defensive tackle Rene Konga (90) pressures Georgia Tech quarterback Haynes King (10)

Louisville DL Rene Konga Named to PFF's National Team of the Week

Sep 21, 2024; South Bend, Indiana, USA; Notre Dame Fighting Irish wide receiver Beaux Collins (5) catches a pass for a touchdown in the second quarter against the Miami Redhawks at Notre Dame Stadium.

Notre Dame Football: ESPN Model Projects Showdown vs. Louisville

Sep 7, 2024; Louisville, Kentucky, USA; Louisville Cardinals head coach Jeff Brohm reacts on the sideline during the second half against the Jacksonville State Gamecocks at L&N Federal Credit Union Stadium. Louisville defeated Jacksonville State 49-14. Mandatory Credit: Jamie Rhodes-Imagn Images

Watch: Jeff Brohm, Mark Ivey and Louisville Players Preview Notre Dame

Notre Dame vs. Louisville football odds, picks for Week 5

Notre Dame vs. Louisville football odds, picks for Week 5 game

Sep 21, 2024; South Bend, Indiana, USA; Notre Dame Fighting Irish head coach Marcus Freeman prepares to lead his players onto the field for the game against the Miami Redhawks at Notre Dame Stadium.

Notre Dame Football: Louisville Week a Major Measuring Stick for Marcus Freeman

Sep 21, 2024; Louisville, Kentucky, USA; Louisville Cardinals running back Donald Chaney (21) runs the ball against the Georgia Tech Yellow Jackets during the first half at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images

Kickoff Time, TV Designation Announced for Louisville vs. SMU

Aug 31, 2024; Louisville, Kentucky, USA; Louisville Cardinals defensive back Quincy Riley (3) watches during warmups before facing off against the Austin Peay Governors at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images

Louisville CB Quincy Riley a 'Game-Time Decision' vs. Notre Dame

Sep 21, 2024; Louisville, Kentucky, USA; Louisville Cardinals wide receiver Jadon Thompson (2) runs the ball against Georgia Tech Yellow Jackets defensive back Ahmari Harvey (3) during the second half at L&N Federal Credit Union Stadium. Louisville defeated Georgia Tech 31-19. Mandatory Credit: Jamie Rhodes-Imagn Images

Louisville WR Jadon Thompson Out For Remainder of Season

What the oddsmakers are predicting for college football's Week 5 games, including the huge Georgia-Alabama matchup.

College football odds, schedule for Week 5: Georgia favored over Alabama

Aug 31, 2024; Pittsburgh, Pennsylvania, USA; Pittsburgh Panthers quarterback Eli Holstein (10) leads the band in the playing of the PITT Alma Mater after defeating the Kent State Golden Flashes at Acrisure Stadium. Pittsburgh won 55-24.Mandatory Credit: Charles LeClaire-Imagn Images

Week 5 ACC Power Rankings: Miami Holds Strong While The Panthers Continue To Prowl

Sep 21, 2024; Louisville, Kentucky, USA; Louisville Cardinals wide receiver Jadon Thompson (2) runs the ball against Georgia Tech Yellow Jackets defensive back Ahmari Harvey (3) during the second half at L&N Federal Credit Union Stadium. Louisville defeated Georgia Tech 31-19. Mandatory Credit: Jamie Rhodes-Imagn Images

Final Thoughts and Observations on Louisville vs. Georgia Tech

Aug 31, 2024; Louisville, Kentucky, USA; Louisville Cardinals head coach Jeff Brohm watches during warmups before facing off against the Austin Peay Governors at L&N Federal Credit Union Stadium.

Despite Miscues, Jeff Brohm 'Proud' of Louisville's Resiliency in Win over Georgia Tech

Sep 21, 2024; Louisville, Kentucky, USA; Louisville Cardinals quarterback Tyler Shough (9) looks to pass against the Georgia Tech Yellow Jackets during the second half at L&N Federal Credit Union Stadium. Louisville defeated Georgia Tech 31-19. Mandatory Credit: Jamie Rhodes-Imagn Images

Louisville Football Climbs Up Week Five AP Top 25 Poll