LSU vs. USC Odds: The Betting Lines for LSU Football's Week 1 Matchup

Brian Kelly and the LSU Tigers continue preparation for their season opener against the USC Trojans, betting lines shifting.

No. 13 LSU will hop on a flight later this week to take on the No. 23 ranked USC Trojans in Las Vegas for a Week 1 showdown.

For the Tigers, the program is in search of their first season opening victory since 2019 with Joe Burrow and Co. at the helm of the program.

The lights will be brighter than ever in Allegiant Stadium, but LSU offensive lineman Will Campbell isn't letting the distractions of Vegas phase him.

“That’s not what we’re there for. We’re there to play football. I’m not there for all the other stuff. The only time I’m going to Vegas is to play football. Everybody knows we’re going there for one reason only. We aren’t going to Caesars Palace, we’re going to play USC.”

It's the city of gambling and there will be significant money tossed around for LSU vs. USC in Week 1.

What are the latest betting odds? Who's the favorite heading into Sunday?

How to Watch: LSU vs. USC

Time: 7:30 p.m. ET
Channel: ABC
Location: Allegiant Stadium in Las Vegas

LSU LT Will Campbell was candid about what to expect heading into Week 1.

The Tigers will hop on a flight to Las Vegas later this week to take on the USC Trojans, but it’s all business.

“We know what we’re there for. It’s not to go to Caesars Palace. It’s to be in a fistfight.” pic.twitter.com/q0OBcDWmYf

— Zack Nagy (@znagy20) August 27, 2024

The Betting Odds:

Point Spread: -4.5 (LSU)
Over/Under: 64.5
Odds: LSU (-184), USC (+152)

All betting odds via FanDuel Sportsbook.

LSU enters the season with a new-look defense under coordinator Blake Baker. With consistency being formed during the offseason, the unit will look to take that next step in 2024.

"What we're going to need is that complement on defense; going to have to play better defense this year. I think we've made the necessary strides in the off-season to continue on that growth," Kelly said during SEC Media Days. "So again, complementary football, offense and defense. I know that sounds like coach speak, but the numbers prove it out. You can't have the No. 1 offense in the country and not play the kind of defense necessary to get you to the next level. Playing better defense quite frankly."

Now, LSU continues game preparation for Lincoln Riley and a fiery Trojans offense with Week 1 just four days away for both programs.

More LSU News:

LSU vs. USC: The Early Betting Lines for Week 1

LSU Inching Towards No. 1 Recruiting Class in America

Nick Saban Calls LSU Quarterback Garrett Nussmeier a "Sleeper" Ahead of 2024 Season

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Follow Zack Nagy on Twitter: @znagy20 and LSU Tigers On SI: @LSUTigersSI for all coverage surrounding the LSU program.