Florida State vs. Clemson odds, spread, line, Week 4 college football game betting picks

Early betting info as Florida State and Clemson meet in this epic ACC conference clash with College Football Playoff implications

A pair of ACC conference rivals meet up in Death Valley as one of several intriguing and impactful games set to kick off this weekend as No. 4 ranked and undefeated Florida State heads into Clemson in college football's Week 4 action on Saturday.

The Seminoles played a close one at Boston College last weekend after a slow start, an injury scare involving quarterback Jordan Travis, and a late rally from the Eagles, but escaped with a 2-point win and got bumped down a spot in the AP top 25 poll.

Clemson is already at one loss on the year following the surprise upset at Duke in the opener, but responded with dominant performances against the likes of Charleston Southern and FAU, outscoring both 114 to 31 in those games.

Here are the early lines and betting trends for you to know as the Seminoles and Tigers square off this weekend.

Florida State vs. Clemson game odds

Courtesy of BetMGM

Line: Florida State -2.5
Total: 55.5 (O -105, U -115)
ML: FSU -135, CLEM +115
FPI pick: Florida State 57.3% to win

Betting trends

+ Seminoles are 13-6 against the spread in last 19 games

+ Total went over in FSU's last 6 overall

+ FSU is 0-5 ATS in last 5 against Clemson

+ Noles are 6-1 ATS in last 7 road games

+ Clemson is 2-4 against the spread in last 6 games

+ Total went over in 5 of Clemson's last 6 vs. Seminoles

+ Clemson is 2-12 ATS in last 14 September games

Want to bet on Clemson vs. Florida State? Here's how

Join FanDuel here to claim $200 worth of bonus bets after wagering just $5 on any game, including Clemson vs. Florida State.

Claim $200 in Bonus Bets instantly when you Bet $5 with DraftKings as the Seminoles and Tigers square off this weekend.

Get $200 in Bonus Bets with Bet365 here when you Bet Just $1 on any college football game.

Get up to $1,000 in Bonus Bets with Points Bet right here.

Or get $1,500 paid back in bonus bets from BetMGM if you don’t win. 

Florida State vs. Clemson schedule

When: Sat., Sept. 23
Time: 12 p.m. Eastern
TV: ABC network
Stream live: fuboTV (Try for free)

---

More college football from SI: Top 25 Rankings | Schedule | Teams

Follow College Football HQ: Bookmark | Rankings | Picks