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Florida State vs. Clemson odds, spread, line, Week 4 college football game betting picks

Early betting info as Florida State and Clemson meet in this epic ACC conference clash with College Football Playoff implications
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A pair of ACC conference rivals meet up in Death Valley as one of several intriguing and impactful games set to kick off this weekend as No. 4 ranked and undefeated Florida State heads into Clemson in college football's Week 4 action on Saturday.

The Seminoles played a close one at Boston College last weekend after a slow start, an injury scare involving quarterback Jordan Travis, and a late rally from the Eagles, but escaped with a 2-point win and got bumped down a spot in the AP top 25 poll.

Clemson is already at one loss on the year following the surprise upset at Duke in the opener, but responded with dominant performances against the likes of Charleston Southern and FAU, outscoring both 114 to 31 in those games.

Here are the early lines and betting trends for you to know as the Seminoles and Tigers square off this weekend.

Florida State vs. Clemson game odds

Courtesy of BetMGM

Line: Florida State -2.5
Total: 55.5 (O -105, U -115)
ML: FSU -135, CLEM +115
FPI pick: Florida State 57.3% to win

+ Seminoles are 13-6 against the spread in last 19 games

+ Total went over in FSU's last 6 overall

+ FSU is 0-5 ATS in last 5 against Clemson

+ Noles are 6-1 ATS in last 7 road games

+ Clemson is 2-4 against the spread in last 6 games

+ Total went over in 5 of Clemson's last 6 vs. Seminoles

+ Clemson is 2-12 ATS in last 14 September games

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Florida State vs. Clemson schedule

When: Sat., Sept. 23
Time: 12 p.m. Eastern
TV: ABC network
Stream live: fuboTV (Try for free)


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