Ohio State vs. Notre Dame odds, spread, line, Week 4 college football game betting picks

Early betting intel on the Ohio State vs. Notre Dame matchup as the Week 4 college football schedule draws near

This weekend brings us a rematch of last season's opener, this time under the watchful eyes of Touchdown Jesus as a pair of undefeated, ranked teams square off with Ohio State paying a visit to Notre Dame in college football's Week 4 action on Saturday.

Sam Hartman is already over 1,000 yards passing in four games for the Irish this season, throwing for 13 touchdowns behind an attack good for almost 509 yards per game, aided by a backfield tandem posting 205 yards on the ground, led by Audric Estime, coming off a 176 yard showing last week and already to 521 yards on the year.

Ohio State's offense came to life in a 63-10 win over Western Kentucky last week as quarterback Kyle McCord hit 19 of 23 passes for 318 yards and three touchdowns. Marvin Harrison, Jr. and Emeka Egbuka lead a wide receiver room that is arguably the best in college football and the Buckeyes present a formidable front against the run, allowing just 83 yards per game on the ground so far.

Here are the early lines and betting trends you should know as the Buckeyes prepare to square off against the Fighting Irish.

Ohio State vs. Notre Dame odds

Courtesy of BetMGM

Line: Ohio State -3
Total: 54.5 (O 105, U -115)
ML: OSU -150 | ND +125
FPI pick: Ohio State 66% to win

Betting trends

+ Ohio State is 3-6 against the spread in its last 9 games

+ Notre Dame is 4-1 ATS in its last 5 games

+ Buckeyes are 4-1 ATS in their last 5 against Notre Dame

+ Total went over in ND's last 5 home games

+ Total went over in 5 of Ohio State's last 7 games on Saturday

+ Total went over in 10 of Notre Dame's last 11 games

+ OSU is 1-4 against the spread in its last 5 games as the favorite

+ Irish are 6-14 SU in their last 20 games as the underdog

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Ohio State vs. Notre Dame schedule

When: Sat., Sept. 23
Time: 7:30 p.m. ET, 6:30 p.m. CT
TV: NBC network
Stream live: fuboTV (Try for free)

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