Colorado vs. Oregon score prediction by college football computer model

Expert score predictions for Colorado vs. Oregon in this Week 4 college football game as Prime's team faces another critical road test

So far, so perfect are these two Pac-12 rivals, the one expected to be so, and the other surprising all the analysts and experts through three games as Colorado hits the road to take on Oregon in college football's Week 4 action on Saturday.

One of six head-to-head games featuring teams in the AP top 25 rankings this week, Deion Sanders and Colorado are 3-0 to start, well outpacing preseason expectations thanks to some dynamic play from a battery of elite skill players, while Oregon boasts its own rotation of game-changers, led by quarterback Bo Nix.

What can we expect when things kick off? Let's check in on how the SP+ prediction model devised by ESPN analyst Bill Connelly projects the matchup, along with the latest betting information for the Week 4 game.

Colorado vs. Oregon predictions

Colorado vs. Oregon score predictions / USA Today Images

Score prediction: The SP+ model is siding very strongly with Oregon, which is projected to defeat Colorado by a score of 46 to 17, according to the simulations, boasting a 95 percent chance of victory.

Point spread: That should be enough to cover the spread, which lists Oregon as the 21.5 point favorites in the game, according to the lines at SI Sportsbook. The projected 63 total points would hit the under of 70.5 points.

FPI prediction: Oregon is another big favorite according to College Football Power Index, another computer simulation model that predicts the Ducks have the 93.8 percent chance to win outright, based on 20,000 replications of the game.

Where the bets are: The spread consensus pick finds most bettors siding with Colorado, as 70 percent of wagers are predicting the Buffaloes to cover the spread as 20.5 point underdogs, and 56 percent of bets siding with the under.

Betting trends: CU is 4-11 ATS in its last 15 games... Total went over in 5 of CU's last 6 games... Ducks are 9-3 ATS in their last 12 games... Total went under in 6 of Oregon's last 8 games.

Want to bet on Colorado vs. Oregon? Here's how

Join FanDuel here to claim $200 worth of bonus bets after wagering just $5 on any game, including Oregon vs. Colorado.

Claim $200 in Bonus Bets instantly when you Bet $5 with DraftKings as the Buffaloes and Ducks square off on Saturday.

Get $200 in Bonus Bets with Bet365 here when you Bet Just $1 on any college football game.

Get up to $1,000 in Bonus Bets with Points Bet right here.

Or get $1,500 paid back in bonus bets from BetMGM if you don’t win.

Colorado vs. Oregon schedule

When: Sat., Sept. 23
Time: 1:30 p.m. MT, 12:30 p.m. PT
TV: ABC network
Stream live: fuboTV (Try for free)

---

More college football from SI: Top 25 Rankings | Schedule | Teams

Follow College Football HQ: Bookmark | Rankings | Picks