Clemson vs. Louisville odds, spread, lines: Week 11 college football picks, predictions by computer model

Picks and predictions for Clemson vs. Louisville on the Week 11 college football schedule

A pair of ACC rivals meet up in Death Valley as Clemson welcomes Louisville in college football's Week 11 action on Saturday.

Louisville comes in behind a four-game win streak that includes a dominant performance against Wake in which the Cardinals forced eight takeaways including two pick-sixes for the 48-21 victory.

Clemson is coming off its first loss of the season, a troubling 35-14 decision on the road against then-unranked Notre Dame that puts a damper on the Tigers' hopes of making the College Football Playoff this year.

What do the experts think of the matchup? Let's see how the College Football Power Index computer prediction model projects the game.

Clemson vs. Louisville picks, predictions

Week 11 college football picks: Clemson vs. Louisville / USA Today Images

Clemson's chance of victory: The computers project Clemson has the 76.2 percent chance to defeat Louisville and avoid a costly second loss on the year.

Louisville's chance of victory: That leaves the Cardinals a 23.8 percent shot to upset the Tigers and move above .500 in ACC competition.

Clemson vs. Louisville point spread: Clemson comes into the game a narrow 7 point favorite to defeat Louisville, according to the lines at SI Sportsbook.

Over/under: 52 points

Moneyline: Clemson -300, Louisville +200

How to watch: The game is set for Sat., Nov. 12 at 3:30 p.m. Eastern on the main ESPN network and streams on fuboTV (Start your free trial).

Clemson predictions: Still the favorites in the ACC, the Tigers check in at No. 8 on the index's 131 college football rankings, which slot teams by a projected per-game scoring margin against average teams on a neutral field. On that score, Clemson is 17.0 points better, projected to win 11.3 games this season, and owns the 74.2 percent likelihood of winning the conference title.

Louisville predictions: Sitting at third in the ACC according to the computer's rankings, the Cardinals are expected to win 7.4 games this season and be 10.2 points better on a neutral field against an average team.

College Football Power Index

Football Power Index (FPI) college football rankings and computer prediction model are a measure of team strength that predicts a team’s future performance.

Rankings and scores predictions are based on 20,000 simulations of a team’s season, using a combination of analytics, including scores to date, quality of opponents, and a team’s schedule.

College football rankings

According to AP top 25 poll

1. Georgia (62 1st-place votes)
2. Ohio State (1)
3. Michigan
4. TCU
5. Tennessee
6. Oregon
7. LSU
8. USC
9. UCLA
10. Alabama
11. Ole Miss
12. Clemson
13. Utah
14. Penn State
15. North Carolina
16. Tulane
17. NC State
18. Texas
19. Liberty
20. Notre Dame
21. Illinois
22. UCF
23. Kansas State
24. Washington
25. Florida State

More college football from SI: Top 25 Rankings | Schedule | Alabama | Georgia | LSU | Ohio State | Michigan | Notre Dame | Tennessee | USC | Clemson | Oklahoma | Texas | All Teams

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