Michigan vs. Colorado State odds, spread, line: 2022 college football picks, Week 1 predictions

College Football Power Index picks, prediction for Michigan vs. Colorado State

Defending Big Ten champion Michigan opens the 2022 college football season at home in the Big House against Colorado State on Saturday.

And our first look at the Wolverines' new look pass rush combined with what should be a dynamic offensive group led by quarterback Cade McNamara.

What do the experts think of the matchup between the Wolverines and the Rams? Let's see how the ESPN computer predicted the game.

Michigan vs. Colorado State football prediction

Michigan opens the 2022 college football schedule against Colorado State

Football Power Index predictably gives Michigan the edge in the matchup, with a huge 97.6 percent chance to win the Week 1 opener.

By contrast, CSU has just a 2.4 percent shot to upset the Wolverines.

The books are also siding heavily with Michigan, which is a 30.5 point favorite to win the game, according to Caesars Sportsbook.

Michigan placed No. 6 overall in the FPI college football rankings, good for second in the Big Ten with 16.2 percent odds to make the playoff again.

The computer predicts UM will win 9.5 games this season.

College Football Power Index

ESPN Football Power Index (FPI) college football rankings are a measure of team strength that predicts a team’s future performance.

Rankings and scores predictions are based on 10,000 simulations of a team’s season, using a combination of analytics, including scores to date, quality of opponents, and a team’s schedule.

College football rankings

According to AP Top 25 poll

1. Alabama
2. Ohio State
3. Georgia
4. Clemson
5. Notre Dame
6. Texas A&M
7. Utah
8. Michigan
9. Oklahoma
10. Baylor
11. Oregon
12. Oklahoma State
13. NC State
14. USC
15. Michigan State
16. Miami
17. Pittsburgh
18. Wisconsin
19. Arkansas
20. Kentucky
21. Ole Miss
22. Wake Forest
23. Cincinnati
24. Houston
25. BYU

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