Michigan vs. Indiana odds, spread, lines: Week 6 college football picks, predictions by computer model

College football picks, predictions for Michigan vs. Indiana for Week 6

Michigan takes it on the road for a second straight week in the Big Ten as the Wolverines square off against Indiana in college football's Week 6 action on Saturday.

Perfect through five games, Michigan is one of the nation's premier scoring offenses and faces a Hoosier squad that's allowed 80 points the last two weeks, both losses.

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What do the experts think of the matchup? Let's see how the College Football Power Index computer prediction model projects the game.

Michigan vs. Indiana odds, spread, predictions

Week 6 college football picks: Michigan vs. Indiana

The computer is going heavily with the visitors, as Michigan has the big 91.9 percent chance to defeat Indiana this weekend.

That leaves IU the 8.1 percent shot to upset the Wolverines at home.

The oddsmakers project an easy time for Michigan, which comes into the game as 21.5 point favorites, according to the line at SI Sportsbook, which set the over/under at 57.5 points for the matchup.

Related: College football Week 6 betting lines, point spreads

Michigan placed No. 4 in the index's 131 college football rankings this week, and the computer projects UM will win 10.7 games on the season, finishing just behind Ohio State in the final Big Ten football predictions.

The computer gives the Wolverines a big 40.7 percent chance to make the College Football Playoff, second to OSU in the conference, and to be 20.0 points better on average than the teams on their schedule.

Indiana checks in at No. 79 on the national index rankings, a drop of 4 spots from last week with an estimate to win 4.3 games this season.

College Football Power Index

Football Power Index (FPI) college football rankings and computer prediction model are a measure of team strength that predicts a team’s future performance.

Rankings and scores predictions are based on 20,000 simulations of a team’s season, using a combination of analytics, including scores to date, quality of opponents, and a team’s schedule.

College football rankings

According to AP top 25 poll

1. Alabama
2. Georgia
3. Ohio State
4. Michigan
5. Clemson
6. USC
7. Oklahoma State
8. Tennessee
9. Ole Miss
10. Penn State
11. Utah
12. Oregon
13. Kentucky
14. NC State
15. Wake Forest
16. BYU
17. TCU
18. UCLA
19. Kansas
20. Kansas State
21. Washington
22. Syracuse
23. Mississippi State
24. Cincinnati
25. LSU

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