NFL Fans Can't Believe 49ers' Luck After Latest RB Goes Down With Injury

Isaac Guerendo's injury has fans questioning whether the 49ers are cursed.

San Francisco 49ers running back Isaac Guerendo on the field before the start of the game against the Chicago Bears. / Cary Edmondson-Imagn Images

The San Francisco 49ers have been bitten badly by the injury bug during the 2024 NFL season. No position on the roster has dealt with more setbacks than the running backs room, which entered play on Sunday with running backs Christian McCaffrey, Jordan Mason and Elijah Mitchell on IR.

Things only worsened during the win against the Chicago Bears. Fourth-string running back Isaac Guerendo, who drew the start in the absence of his aforementioned teammates, exited the game during the second half after picking up an injury of his own.

Kyle Shanahan provided an update on Guerendo after the game and told reporters that the team believes he suffered a sprained foot, but he'd require an MRI to determine the severity of the injury.

Guerendo's is the latest in a laundry list of injuries to plague the 49ers this season, and fans on social media couldn't help but note just how unlucky the team has been in terms of keeping its key players on the field.

49ers RB injury recap:
RB1: Christian McCaffrey (injured reserve)
RB2: Elijah Mitchell (injured reserve)
RB3: Jordan Mason (injured reserve)
RB4: Isaac Guerendo (heading to the locker room)

— Danny Heifetz (@Danny_Heifetz) December 9, 2024

Just end this season already man https://t.co/K73CT5W7GR

— Alex 👋 (@Dubs408) December 9, 2024

This season is straight cursed for the 49ers. https://t.co/hcy8ahAbX2

— Jake Hatch (Yawk) Utah Hockey Club Aficionado (@JacobCHatch) December 9, 2024

At this rate, newly signed Israel Abanikanda is going to voluntarily retire rather than risk injury as a 49ers RB

— Brian Renick 🗣️🎙️ (@brenick77) December 9, 2024

49ers are cursed, would hate to be a runningback on this team

— Thechek182 (@thechek182) December 9, 2024

49ers running backs are cursed this year. Jeeze.

— GK Sports Gambling (@GKSportsGamblin) December 9, 2024

Dang! The 49ers can't catch a break... except every time they do! Speedy recovery!

— Matthew Murrie (@MattMurrie) December 9, 2024

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