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49ers DE Nick Bosa to Miss Second Game in a Row with an Oblique Injury

The 49ers will have to prove they can stop the run without Bosa on the field if they're going to pull off the upset.

Grant Cohn

Oct 27, 2024; Santa Clara, California, USA; San Francisco 49ers defensive lineman Nick Bosa (97) warms up before the game against the Dallas Cowboys at Levi's Stadium. Mandatory Credit: Kelley L Cox-Imagn Images
Oct 27, 2024; Santa Clara, California, USA; San Francisco 49ers defensive lineman Nick Bosa (97) warms up before the game against the Dallas Cowboys at Levi's Stadium. Mandatory Credit: Kelley L Cox-Imagn Images / Kelley L Cox-Imagn Images
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The 49ers won't have their best pass rusher when they face the Bills on Sunday.

Nick Bosa will miss his second game in a row with an oblique injury he suffered Week 11 against the Seahawks. He didn't practice at all this week. Kyle Shanahan said he's not sure when Bosa will return.

Bosa originally injured his oblique in practice about a month ago, but he played through that injury, overcompensated for it and eventually hurt his other oblique even worse as a result. Now he's being cautious with his return, which is understandable. Because if he returns too soon, he could injure it even worse to point where it could require offseason surgery.

Since 2019 when the 49ers drafted Bosa, their record is just 5-11 in games he doesn't play. Last week when he was out, the defense gave up 168 rushing yards and 38 points. Now they have to face the Bills in Buffalo without him. The last time the 49ers faced the Bills -- 2020 -- Bosa also didn't play, and the 49ers gave up 34 points and lost and Josh Allen threw for 375 yards and four touchdowns.

This time around, the 49ers have a quality secondary -- it limited Packers quarterback Jordan Love to just 163 passing yards last week. Unfortunately for the 49ers, they missed 19 tackles and got manhandled in the trenches.

The 49ers will have to prove they can stop the run without Bosa on the field if they're going to pull off the upset.

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Grant Cohn
GRANT COHN

Grant Cohn has covered the San Francisco 49ers daily since 2011. He spent the first nine years of his career with the Santa Rosa Press Democrat where he wrote the Inside the 49ers blog and covered famous coaches and athletes such as Jim Harbaugh, Colin Kaepernick and Patrick Willis. In 2012, Inside the 49ers won Sports Blog of the Year from the Peninsula Press Club. In 2020, Cohn joined FanNation and began writing All49ers. In addition, he created a YouTube channel which has become the go-to place on YouTube to consume 49ers content. Cohn's channel typically generates roughly 3.5 million viewers per month, while the 49ers' official YouTube channel generates roughly 1.5 million viewers per month. Cohn live streams almost every day and posts videos hourly during the football season. Cohn is committed to asking the questions that 49ers fans want answered, and providing the most honest and interactive coverage in the country. His loyalty is to the reader and the viewer, not the team or any player or coach. Cohn is a new-age multimedia journalist with an old-school mentality, because his father is Lowell Cohn, the legendary sports columnist for the San Francisco Chronicle from 1979 to 1993. The two have a live podcast every Tuesday. Grant Cohn grew up in Oakland and studied English Literature at UCLA from 2006 to 2010. He currently lives in Oakland with his wife.

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