49ers vs. Bills: Live Updates and Analysis

This is the live blog from the San Francisco 49ers Week 13 home game from Glendale, Arizona against the Buffalo Bills.

This is the live blog from the San Francisco 49ers Week 13 home game from Glendale, Arizona against the Buffalo Bills. I will update this frequently with information and analysis from my living room.

3:50 Here are the 49ers inactives:

Trent Taylor

K'Waun Williams

Emmanuel Moseley

Austin Walter

3:51 The 49ers won't have their top-three nickelbacks -- Williams, Moseley and Jamar Taylor, who tore his ACL last week against the Rams. It's unclear who will play nickelback in this game. Perhaps it will be Jimmie Ward. Or, perhaps it will be Jason Verrett. He could move inside when the 49ers are in their nickel defense, and Ahkello Witherspoon could replace him at outside corner. That's a scary thought.

3:52 Perhaps Tim Harris Jr. will replace Verrett at outside corner if/when Verrett moves to the slot. The 49ers called up Harris from the practice squad to the active roster on Monday.

3:53 Trent Taylor is inactive, which is intriguing. Taylor typically returns punts for the 49ers, so who will take it place? It could be Richie James Jr., but he fumbled a punt three weeks ago against the New Orleans Saints. I'm guessing rookie Brandon Aiyuk will make his NFL debut as a returner in this game. He's one of the 49ers best players, and they have to find as many ways as possible to get him the ball in order to win this game. Plus, Eagles rookie wide receiver Jalen Reagor returned a punt for a touchdown last night, and he's a first-round pick. Why can't Aiyuk return punts, too?

5:14 The 49ers win the toss and defer. The Bills get the ball first.

FIRST QUARTER

5:28 On fourth and goal from the 1, Josh Allen throws an incomplete pass late and behind tight end Lee Smith, who was open. The Bills turn it over on downs.

5:42 On fourth and goal from the 1, Jeff Wilson Jr. runs for no gain. The 49ers turn it over on downs. What a start to this game.

5:43 First play of the drive, Bills running back Zack Moss fumbles and the 49ers recover. Wow! What a freaking game.

5:45 On third and goal from the 2, Nick Mullens throws a play-action touchdown pass to Brandon Aiyuk.

49ers 7, Bills 0.

SECOND QUARTER

5:59 On first and goal from the 5, Richard Sherman gives up a touchdown catch to Cole Beasley.

49ers 7, Bills 7.

6:00 Josh Allen keeps escaping the pocket to his right. The 49ers need to use a three-man game on the defensive line with a the nose tackle looping to the offense's right to contain Allen.

6:05 On third and 5 from the 49ers 37, Jordan Reed reaches out and breaks up a pass intended for Kendrick Bourne. Odd play. The 49ers punt.

6:19 On first and goal from the 4, Allen throws a touchdown pass to tight end Dawson Knox.

49ers 7, Bills 14.

6:26 On third and 6 from the Bills 46, Colton McKivitz gives up a quarterback hit. Mullens still gets the throw off to Aiyuk, but he drops it. The 49ers punt it to the Bills 10.

6:33 The Bills make a 37-yard field goal as the first half ends.

49ers 7, Bills 17.

6:34 Robert Saleh keeps calling zone coverage because Richard Sherman can't cover man to man, and Allen is shredding the zones.

THIRD QUARTER

6:53 On third and 12 from the Bills 27, Mullens throws the ball away. Next play, Robbie Gould makes a 45-yard field goal.

7:09 On second and 9 from the 49ers 23, Robert Saleh calls man to man coverage, and Tarvarius Moore misses his assignment, covers the wrong person and gives up a touchdown catch to Isaiah McKenzie.

49ers 10, Bills 24.

7:12 Kentavius Street extended the drive with a mindless late hit on Josh Allen on second and 18. Would have third and 18 had Street not made that mistake.

7:15 On second and 10, Brandon Aiyuk drops a pass and tips it to the Bills who intercept it and return it to the 49ers 5-yard line.

7:18 The 49ers defense pushes the Bills backward. Buffalo makes a 28-yard field goal.

49ers 10, Bills 27.

7:26 On first and 10 from the Bills 45, Mullens throws a beautiful 39-yard deep pass to Aiyuk. Next play, Mullens throws a touchdown pass in the flat to Kyle Juszczyk. Clutch drive.

49ers 17, Bills 27.

FOURTH QUARTER

7:40 On second and 10 from the 49ers 28, Richard Sherman gives up a touchdown pass to Gabriel Davis. Sherman was playing deep zone coverage and let Davis run right by him. Time for Sherman to move to free safety full time. He's not a good corner anymore.

49ers 17, Bills 34.

7:47 7:53 On third and goal from the 6, Tre'Davious White intercepts Mullens, who was throwing to Jeff Wilson Jr. White just ripped the ball away. Great play. Game over, essentially.

7:59 With 3:44 left in the game, the Bills punt for the first time. Embarrassing. Aiyuk returns the punt 16 yards.

8:11 On third and 1 from the Bills 5, Mullens scrambles to his right and throws a touchdown pass to Jordan Reed.

49ers 24, Bills 34.

Bills win. Stay tuned for my grades.