Update: Nick Bosa and Other Key 49ers to Miss Game

49ers edge rusher Nick Bosa had been declared doubtful for Sunday's game with a hip/oblique injury but on Saturday the team ruled him out.

Nick Bosa pursues former Bears QB Justin Fields in the 2021 matchup between the teams at Soldier Field. / Dennis Wierzbicki-Imagn Images

The big edge the 49ers have on both sides of the football matching up against the Bears no longer exists.

The won't face 49ers left tackle Trent Williams or edge rusher Nick Bosa.

Williams was declared out for the game with the Bears Sunday with an ankle injury and Bosa had been listed as doubtful. However, on Saturday the 49ers downgraded Bosa to out for the game and

Bosa has a hip/oblique injury and didn't practice all week. Bosa, who has eight sacks, last played on Nov. 17.

Those aren't the only starters out for the 49ers.

Starting guard Aaron Banks missed the loss last week to Buffalo with a concussion and had been questionable for the game but he failed to escape NFL protocol and was also ruled out Saturday. He started every game before the concussion he suffered against Green Bay two weeks ago.

Running back Jordan Mason has been the replacement for Christian McCaffrey, who suffered what is likely to be a season-ending knee injury. Mason leads the 49ers in rushing this season but has an ankle injury and is out for the game.

Without those two, the Niners would likely rely on speedy Isaac Guerendo,

Others the 49ers declared as out are linebacker Dre Greenlaw (Achilles) and safety George Odu (knee).

Linebacker Demetrius Flannigan-Fowles (knee) and safety Talanoa Hufanga (wrist) are questionable after they practiced on a limited basis Friday but are being counted on for a return.

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