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The Buffalo Bills head to Indianapolis in Week 10 looking to continue their winning ways against the Colts.

The Buffalo Bills are set to host the Dolphins in a game that will likely determine the fate of Miami's season.

The Buffalo Bills head to the west coast to take on the Seattle Seahawks in a Week 8 matchup.

The Buffalo Bills return to Orchard Park to host the 1-4 Tennessee Titans in what has the makings of a blowout.

Previewing the Buffalo Bills vs. New York Jets Week #6 AFC East matchup

The Buffalo Bills will look to get back in the win column in a Week 5 clash with the Houston Texans.

Josh Allen and the Buffalo Bills head down to Baltimore to take on Lamar Jackson and friends in a critical AFC matchup.

The Buffalo Bills take on the Jacksonville Jaguars in a Week 3 battle which may be season-defining for both teams.

The Buffalo Bills head down to Miami to yet again stake their claim as the King of the AFC East.

The Buffalo Bills enter Week 1 with a lot to prove against an Arizona Cardinals team far too many people are sleeping on.

The new-look Buffalo Bills enter a pivotal season with their eyes set on a fifth straight division title and a larger prize past that.

The Buffalo Bills' road to a sixth-straight postseason appearance goes through the AFC East. Here's an in-depth breakdown of the New York Jets.