Buffalo Bills vs. L.A. Rams Week 1: How to Watch, Betting Odds

The Bills and the Rams kick off the NFL season Thursday at SoFi Stadium.

The Buffalo Bills travel west to kick off the 2022 NFL season on Thursday Night Football in Los Angeles against the Rams.

The 2022-23 Buffalo squad tries to improve on an 11-6 campaign and take the AFC East division crown. Motivation is sky-high for a Bills team that is still feeling the effects of last season's heart-breaking AFC Divisional loss.

The NFL is finally back and there might not be a more exciting matchup available to watch in Week 1 when two teams with high-powered offenses and well-rounded defenses will take the field. 

Quarterbacks Josh Allen of Buffalo and Matthew Stafford of Los Angeles will no doubt put on a show while both team's defenses - led by the Rams' Aaron Donald and the Bills' Von Miller - attempt to contain them.

The two teams last met during the 2020 season, and it went right down to the wire, with Allen throwing a touchdown pass with 15 seconds left for a 35-32 home victory.

On their inaugural injury report of 2022, the Bills have officially listed safety Jordan Poyer (elbow) and wide receiver Isaiah McKenzie (groin) as full participants; lending strong credence to each player suiting up for their season opener.

WHAT: Buffalo Bills (0-0) vs. Los Angeles Rams (0-0)

WHEN: Thursday, Sept. 8, 8:20 p.m. ET

WHERE: SoFi Stadium, Inglewood, California (70,000)

TELEVISION: NBC / FuboTV (try it free)

RADIO: WGR550 (550 AM)

Betting vis SI SportsBook

SPREAD: Buffalo Bills -2.5

TOTAL: 51.5 (o -110, u -110)

MONEYLINE: Bills -113, Rams +110

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