McCaffrey racked up 2,023 total yards in 16 games for the 49ers last season.

Christian McCaffrey to Miss At Least Four Games As 49ers Place Star on IR

Tom Dierberger
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Sep 9, 2024; Santa Clara, California, USA; San Francisco 49ers wide receiver Brandon Aiyuk (11) is introduced to the crowd before the game against the New York Jets at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

The 49ers Need Brandon Aiyuk to Step Up During McCaffrey's Absence

Grant Cohn
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Sep 9, 2024; Santa Clara, California, USA; San Francisco 49ers fullback Kyle Juszczyk (44) talks with running back Christian McCaffrey (23) on the sideline during the second quarter against the New York Jets at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

How the 49ers Offense Changes when Christian McCaffrey is Out

Grant Cohn
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August 18, 2024; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) watches warm ups before the game against the New Orleans Saints at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images

The 49ers Should Sign a Running Back if Christian McCaffrey Goes to IR

Grant Cohn
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Schedule
Standings
Injuries
Sep 9, 2024; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) watches injured from the sidelines in the second quarter against the New York Jets at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

Have the 49ers Mismanaged Christian McCaffrey's Achilles Tendonitis?

Grant Cohn
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Burrow has a 3-1 record against the Chiefs, including 1-1 at Arrowhead.

NFL Week 2 Watchability Index: Top 10 Games to Watch

Matt Verderame
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McCaffrey missed the 49ers' season-opening win over the Jets due to a calf injury and Achilles tendonitis.

NFL Issues Statement After Investigating 49ers for Christian McCaffrey Injury Fiasco

Patrick Andres
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Sep 9, 2024; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) watches from the sideline due to injury during the second quarter against the New York Jets at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

49ers RB Christian McCaffrey Will be Inactive Against the Vikings

Jose Sanchez
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McCaffrey rushed for 1,459 yards in 16 games with San Francisco last season.

49ers to Consider Placing Christian McCaffrey on Injured Reserve

Tom Dierberger
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Oct 23, 2023; Minneapolis, Minnesota, USA; Minnesota Vikings wide receiver Jordan Addison (3) runs with the ball as San Francisco 49ers linebacker Fred Warner (54) pursues during the game at U.S. Bank Stadium. Mandatory Credit: Jeffrey Becker-Imagn Images

Vikings Will be Without Key WR Against the 49ers in Week 2

Jose Sanchez
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Sep 9, 2024; Santa Clara, California, USA; New York Jets head coach Robert Saleh (left) greets San Francisco 49ers linebacker Fred Warner (right) after the game at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

49ers LB Fred Warner is a "First-Ballot Hall of Famer" Says Robert Saleh

Jose Sanchez
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Sep 9, 2024; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) talks with Monday Night Football's Laura Rutledge after the win against the New York Jets at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

49ers QB Brock Purdy Sizes Up the Minnesota Vikings Defense

Grant Cohn
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Dec 17, 2023; Glendale, Arizona, USA; San Francisco 49ers quarterback Brock Purdy (13) and running back Christian McCaffrey (23) against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images

Brock Purdy on How the 49ers Pass Game Suffers without Christian McCaffrey

Grant Cohn
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Jul 26, 2024; Santa Clara, CA, USA; San Francisco 49ers run game coordinator Chris Foerster talks to the press during Day 4 of training camp at SAP Performance Facility. Mandatory Credit: D. Ross Cameron-Imagn Images

Why the 49ers OL Coach got Upset with Dominick Puni vs. the Jets

Grant Cohn
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Jul 25, 2024; Santa Clara, CA, USA; San Francisco 49ers defensive coordinator Nick Sorensen answers questions at a press conference following Day 3 of training camp at SAP Performance Facility. Mandatory Credit: D. Ross Cameron-Imagn Images

49ers DC Nick Sorensen Gives an Honest Assessment of Sam Darnold

Grant Cohn
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Sep 8, 2024; East Rutherford, New Jersey, USA; Minnesota Vikings quarterback Sam Darnold (14) rolls out to pass against the New York Giants during the second half at MetLife Stadium. Mandatory Credit: John Jones-Imagn Images

How the 49ers will Expose Minnesota Vikings Quarterback Sam Darnold

Grant Cohn
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Mayfield was outstanding in Week 1, throwing for 289 yards and four touchdowns in the Buccaneers' 37-20 win over the Commanders.

NFL Week 2: Best Games, Key Matchups, Fantasy Tips, Best Bets and Predictions

SI Staff
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Feb 6, 2024; Las Vegas, NV, USA; San Francisco 49ers cornerback Deommodore Lenoir (2) during a press conference before Super Bowl LVIII at the Hilton Lake Las Vegas Resort. Mandatory Credit: Kirby Lee-Imagn Images

49ers CB Deommodore Lenoir Says He has Vikings QB Sam Darnold's Number

Grant Cohn
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Darnold was an efficient 19-of-24 and threw for two touchdowns in his first start for the Vikings.

Deommodore Lenoir Throws Not-So-Subtle Shade at Sam Darnold Before 49ers-Vikings

Ryan Phillips
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