Understanding Neuroblastoma: Insights from Dr. Judith Villablanca

Neuroblastoma originates from the sympathetic nervous system, not the brain, commonly found in the adrenal gland, spine, or neck.
Understanding Neuroblastoma: Insights from Dr. Judith Villablanca
Understanding Neuroblastoma: Insights from Dr. Judith Villablanca / The Everyday Warrior Nation

Neuroblastoma is a challenging and aggressive form of cancer, primarily affecting children, and its nature often leads to confusion. During an episode of Power Athlete Radio with Dr. Judith Villablanca, an expert in pediatric oncology, she shed light on the key misconceptions and complexities surrounding this disease.

One of the most common misunderstandings about neuroblastoma stems from its name. Many people assume that it is a type of brain tumor due to the ""neuro"" prefix, which is often associated with the nervous system. However, as Dr. Villablanca explained, neuroblastoma is not a tumor of the brain. Instead, it is a tumor that arises in the sympathetic nervous system, which is responsible for many unconscious bodily functions, such as heart rate and blood pressure regulation.

To fully understand neuroblastoma, it’s crucial to know a bit about the sympathetic nervous system. This system controls the body’s ""fight or flight"" response, managing functions that keep us alert and responsive in stressful situations. Whether it's an elevated heart rate or rising blood pressure when you're startled, these reactions are the result of the sympathetic nervous system in action. Think of it as your body’s idle system, always working in the background and ramping up when needed.

The sympathetic nervous system is part of the autonomic nervous system, which operates without conscious control. It includes various structures, such as the adrenal glands and nerve clusters that run along the spine, that play essential roles in keeping our bodies functioning properly, particularly in stressful situations. The adrenal glands, for instance, sit atop the kidneys and release hormones like adrenaline during stress. Neuroblastoma primarily originates in this area, affecting these nerve tissues.

As Dr. Villablanca noted, neuroblastoma most commonly arises in the adrenal glands, which are part of the sympathetic nervous system. Located on top of the kidneys, the adrenal glands are small, but critical organs responsible for hormone production. In neuroblastoma, abnormal cell growth forms a tumor in these glands. The tumor may also appear in other areas of the sympathetic nervous system, such as along the spine or in clusters of nerve cells located in the neck, specifically in the cervical region.

These locations of neuroblastoma make it a unique and challenging cancer to treat, as it can affect vital parts of the body. Neuroblastoma tumors can grow rapidly and spread to other areas, making early detection and intervention crucial.

One of the reasons neuroblastoma is so challenging is its unpredictable nature. This cancer tends to behave differently depending on the age of the child and the stage at which it's detected. For example, infants with neuroblastoma may sometimes experience spontaneous regression, where the tumor shrinks or disappears without treatment. However, in older children, neuroblastoma is often more aggressive and may have already spread to other organs by the time it is diagnosed.

Furthermore, neuroblastoma is classified as a high-risk cancer when it spreads beyond the original tumor site, often involving the bone marrow, liver, and bones. Once the cancer spreads, treatment becomes more complex. Standard treatment typically includes a combination of surgery, chemotherapy, radiation, and immunotherapy, depending on the extent and location of the cancer.

Dr. Villablanca emphasized that one of the key challenges in neuroblastoma is that it affects very young children, often under the age of five, which can make treatment emotionally and physically challenging for both the patients and their families. The symptoms can be vague, such as fatigue, loss of appetite, or a swollen abdomen, which often leads to delays in diagnosis.

Despite these challenges, there is hope. Dr. Villablanca spoke about the advances in research and treatment for neuroblastoma. In recent years, there has been progress in developing targeted therapies, including immunotherapies that focus on harnessing the body’s immune system to fight the cancer. Clinical trials continue to play a significant role in improving outcomes for children with high-risk neuroblastoma.

Another promising area of research involves understanding the genetic factors that contribute to the development of neuroblastoma. By identifying specific genetic mutations or markers, doctors can better tailor treatment plans to each patient’s needs. Personalized medicine is becoming a key strategy in managing neuroblastoma, giving more children a fighting chance at survival.

Neuroblastoma remains a complex and formidable cancer, but ongoing research and improvements in treatment are providing hope for better outcomes. As Dr. Villablanca highlighted in the podcast, understanding the nature of this disease, especially how it differs from other types of tumors, is crucial in raising awareness and advancing treatment options. By focusing on early detection, innovative therapies, and continued research, the medical community is making strides toward better outcomes for children diagnosed with this challenging disease.


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John Welbourn
JOHN WELBOURN

John Welbourn is Founder/CEO of Power Athlete Inc and former NFL player. John was drafted with the 97th pick in 1999 NFL Draft and went on to be a starter for the Philadelphia Eagles from 1999-2003, appearing in 3 NFC Championship games, and started for the Kansas City Chiefs from 2004-2007. In 2008, he played with the New England Patriots until an injury ended his season early with him retiring in 2009. Over the course of his NFL career, John started over 100 games regular season games with 10 play-off appearances. He was a four-year letterman while playing football at the University of California at Berkeley. He graduated from the college of letters and sciences with a bachelor's degree in Rhetoric in 1998. And did his Masters work at the UC Berkeley School of Education in 1999. Since retiring from the NFL, John has worked extensively with the NFL, NHL, MLB, Olympic athletes, the US Army and Naval Special Warfare. He works as a consultant and advisor for several companies focused on improving human performance through training, nutrition and fitness-based technologies. John provides daily coaching and mentorship to over 5000 athletes around the world through his Power Athlete Coaches Network and training program delivery platform. Since in 2013, John has hosted a weekly podcast, Power Athlete Radio; a podcast dedicated to improving performance and connecting with some of the smartest people on the planet. With more than 700 episodes Power Athlete Radio has proven to be on the top podcasts in the strength and conditioning realm. John travels the world lecturing on performance and nutrition for Power Athlete and as a keynote speaker. John is a married father of three and resides in Austin, Texas. You can catch up with him at his personal blog, “Talk To Me Johnnie”, at Power Athlete or on social media @johnwelbourn.