Serena Williams upset by Roberta Vinci at U.S. Open, Twitter reacts

The world No. 1 is out of the U.S. Open after losing to Roberta Vinci in the semifinals Friday.

Serena Williams is out of the U.S. Open after being upset by unseeded Roberta Vinci in the semifinals Friday 2–6, 6–4, 6–4.

This is the first Grand Slam in her last five appearances that Williams has lost. Williams was attempting to become the first player since Steffi Graf in 1988 to complete the calendar Grand Slam.

Williams has 21 Grand Slam titles, one behind Graf for first in the professional era.

Vinci will move on to face fellow Italian Flavia Pennetta in the final at 3 p.m. ET on Saturday after the tournament’s No. 26 seed upset No. 2 Simona Halep 6–1, 6–3 on Friday.

Following the match, some spoke out on Twitter regarding Serena’s run for history.

So proud of you, @SerenaWilliams. What you did this year was amazing. -mo #USOpen2015

— First Lady- Archived (@FLOTUS44) September 11, 2015

Wow, what a crazy crazy entertaining match. Such a bummer for Serena but a great match between 2 world class athletes.

— Alex Morgan (@alexmorgan13) September 11, 2015

Well when Serena breaks it off with Drake I'm here for you boo. My season is already in the crapper so no one will blame you.

— Lolo Jones (@lolojones) September 11, 2015

Meek mill watching this serena game and laughing to no one in particular

— Desus MF Nice💯 (@desusnice) September 11, 2015

4 grand slam W in a row plus SF and people disappointed. Geez..

— ivo karlovic (@ivokarlovic) September 11, 2015

Tough loss for @serenawilliams today in the @usopen semis. Congrats on a fantastic run and winning 4 majors in a row.

— Nick Bollettieri (@NickBollettieri) September 11, 2015

Don't worry bout it @serenawilliams shake it off get next one!

— Jodie Meeks (@Jmeeks20) September 11, 2015

Vinci serving 4 the match vs @serenawilliams I am stunned

— Dick Vitale (@DickieV) September 11, 2015

Following the match, “Damn Serena,” “Drake,” and “#USOpen2015” were trending on Twitter.

- Kenny Ducey