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Sam Querrey upsets No. 1 and defending champ Andy Murray at Wimbledon

Sam Querrey is the first American man to make a major semifinal since Andy Roddick in 2009.

No. 24-seed Sam Querrey upset No. 1 Andy Murray in the quarterfinals on Wednesday, winning 3-6, 6-4, 6-7, 6-1, 6-1 to advance to the Wimbledon semifinals.

After winning the first set, Querrey fought back to win the second but Murray was able to take the decisive third set in a tiebreak. He looked to be on his way to a four-set victory, but the American steamrolled in the fourth, winning the set 6-1 in just 22 minutes to force a decider. Querrey jumped out to a 3-0 lead in the final set, marking a 9-game streak, before Murray was finally able to get on the board for 3-1. But it wasn't enough for the Scot, who was clearly struggling with an injury. He was unable to serve or hit forehands with regular movements and turned to dropshots frequently.

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Querrey is the first American man to make a Grand Slam semifinal since Andy Roddick at Wimbledon in 2009. Querrey's win also marks the second-straight year the 29-year-old knocked off a World No. 1 and Wimbledon defending champion, after he upset then-World No. 1 and defending champ Novak Djokovic in the third round here last year.

With the loss, Murray could lose the World No. 1 ranking if Novak Djokovic wins the title.