USC vs. Notre Dame game odds, prediction, how to bet Week 7 college football

Betting info for USC vs. Notre Dame and how you can bet on the Week 7 college football game

One of college football's most historic rivalry games returns to the gridiron this weekend, with one side looking to stay in playoff contention, while the other looks to dash those hopes after likely falling out of the race itself. No. 21 Notre Dame welcomes No. 10 USC to South Bend in Saturday's Week 7 action.

Notre Dame likely dipped out of College Football Playoff contention after taking its second loss of the season, a surprise upset on the road against undefeated Louisville, but Sam Hartman and the Irish offense have more than a shot against in this one.

That's because the USC defense doesn't appear to have improved much from last season. The unit directly cost the team in the Pac-12 title game, when a playoff berth was on the line, and again in a loss in the Cotton Bowl. Now, the Trojans rank 109th nationally by allowing 421 yards per game and is 113th against the pass.

USC vs. Notre Dame game odds

Courtesy of SI Sportsbook

Line: Notre Dame -2.5
Total: 60.5 points
Moneyline: ND -143 | USC +115

Early computer predictions

Notre Dame has a projected 61.8 percent to win the game, compared with USC at 38.2 percent, according to the College Football Power Index, a computer predictive tool that simulates games 20,000 times to pick straight-up winners.

The Fighting Irish win out in 12,360 of the 20,000 projections, while the Trojans win in the remaining 7,640 of sims.

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USC vs. Notre Dame schedule

When: Sat., Oct. 14
Time: 7:30 p.m. Eastern
TV: NBC network
Stream live: fuboTV (Try for free)

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