Saints vs. 49ers Lines, Odds, Prediction | Week 12

The New Orleans Saints at San Francisco 49ers game preview, prediction, moneyline, and odds.

Kyle T. Mosley | Nov 27, 2022

Saints vs. 49ers Lines, Odds, Prediction | Week 12 /

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New Orleans Saints

Since the days of Joe Montana, Jerry Rice, Steve Young, Roger Craig, and Ronnie Lott, New Orleans has had less than fond memories of their West Coast trips to meet the 49ers. Bill Walsh assembled those football legends who always had a way of crushing the Saints.

Dec 8, 2019; New Orleans, LA, USA; New Orleans Saints running back Alvin Kamara (41) runs with the ball against the San Francisco 49ers in the second quarter at the Mercedes-Benz Superdome. Mandatory Credit: Chuck Cook-USA TODAY Sports

On Sunday, the task will be to contain Jimmy Garoppolo's offensive weapons in Christian McCaffrey, George Kittle, and Deebo Samuel (hamstring/questionable). The charge will be difficult, yet, New Orleans has a few starters to be active off of the previous week's injury reports.

Cornerback Bradley Roby (ankle) and first-round pick Trevor Penning (foot) will be on the roster for Week 12. After missing his first contest due to injury in 12 seasons, Cam Jordan (eye) may don the black and gold for action. This week, New Orleans didn't sign a new defensive end to replace Payton Turner. Another good sign is that Marcus Davenport will be available to pressure and harass Jimmy Garoppolo.

The Saints ended a two-game skid against the Los Angeles Rams in Week 11. Could they pull off the upset at Levi's Stadium?

New Orleans rides and dies with the play of Andy Dalton. Last, the Red Rifle connected on 84% of his passes for 260 yards and three touchdowns. Taysom Hill's sixteen touches at quarterback eclipsed the magic number of nine for the Saints to win this season. However, Alvin Kamara was a quiet factor with 89 yards of offensive output in the 27-20 victory.

Kaden Elliss, paired with Demario Davis, is a surprise in place of Pete Werner. The linebackers had 19 tackles and two sacks versus the Rams and could affect Jimmy Garoppolo in the pocket. Roby's presence will help support the "Young Guns" Paulson Adebo and Alontae Taylor on the corners. Tyrann Mathieu must have a solid tackling game with a probable matchup with Kittle on several plays.

Kyle Shannahan employs an up-tempo game plan with misdirection and reverses. New Orleans must be disciplined and maintain their assignments, or Deebo Samuel and Christian McCaffrey could have a huge afternoon.

Dec 8, 2019; New Orleans, LA, USA; San Francisco 49ers quarterback Jimmy Garoppolo (10) throws the ball in the second quarter against the New Orleans Saints at Caesars Superdome. Mandatory Credit: Chuck Cook-USA TODAY Sports

New Orleans Saints 2022 Leaders

Andy Dalton 162/242, 1819 yds, 14 TDs
Chris Olave 51 rec, 760 yds, 3 TDs
Alvin Kamara 124 rush, 511 yds, 1 TD

San Francisco 49ers 2022 Leaders

Jimmy Garoppolo 179/267, 2159 yds, 15 TDs
Brandon Aiyuk 46 rec, 587 yds, 6 TDs
Jeff Wilson 92 rush, 468 yds, 2 TDs

Last 5 Matchups: Saints vs. 49ers

Nov 15, 2020 SFO 13, @NOR 27
Dec 8, 2019 SFO 48, @NOR 46
Nov 6, 2016 @SFO 23, NOR 41
Nov 9, 2014 SFO 27, @NOR 24
Nov 17, 2013 SFO 20, @NOR 23

The San Francisco 49ers lead the all-time series 49-27-2

TEAM RANKS

	New Orleans	San Francisco
HOME RECORD	3-4	3-1
AWAY RECORD	1-3	3-3
RECORD VS. SPREAD	4-7	5-5
PPG	22.6 (15th)	23.6 (11th)
PTS ALLOWED/GAME	24.3 (25th)	17.3 (4th)
TAKEAWAY DIFF.	-12 (32nd	-1 (22nd)
PASS YARDS/GAME	237 (7th)	235 (8th)
RUSH YARDS/GAME	117 (15th)	127 (12TH)
DEF. PASS YARDS/GAME	195 (8th)	202 (11th)
DEF. RUSH YARDS/GAME	132 (22nd)	81 (1st)

USATSI_19205149_168388561_lowres — Oct 9, 2022; New Orleans, Louisiana, USA; New Orleans Saints defensive end Cameron Jordan (94) slaps hands with cornerback Bradley Roby (21) after sacking Seattle Seahawks quarterback Geno Smith (7) during the first half at Caesars Superdome. Mandatory Credit: Stephen Lew-USA TODAY Sports

Saints Final Injury Report

Marcus Davenport DE, QUESTIONABLE
J.T. Gray DB, OUT
James Hurst OT
Mark Ingram RB, QUESTIONABLE
Cameron Jordan DE, QUESTIONABLE
Jarvis Landry WR
Marshon Lattimore CB, QUESTIONABLE
Andrus Peat OT, QUESTIONABLE
Ryan Ramczyk OT
Payton Turner DE OUT
Pete Werner LB, OUT
Alvin Kamara RB

Saints vs. 49ers Odds

Moneyline: Saints +350 | 49ers -450
Spread: Saints +9.5 (-110) | 49ers -9.5 (-110)
Total: 43.5 Over (-110) | Under (-110)
Game Info: Sunday, Nov. 27 | 3:25 pm (CT) | Fox
Saints Straight Up Record: 4-7
Saints Against The Spread Record: 4-7
49ers Straight Up Record: 6-4
49ers Against The Spread Record: 5-5
The Saints are 7-3 against the spread in their last ten games as a road underdog, per Bill Enright.

Bet on Saints-49ers at SI Sportsbook

Prediction

Saints 27, 49ers 31

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Published Nov 27, 2022

KYLE T. MOSLEY